Injection during CABG surgery helps failing hearts
نویسندگان
چکیده
منابع مشابه
Failing Human Hearts
Background A variety of previous studies have demonstrated reduced diastolic potential and electrical activity in atrial specimens from patients with heart disease. Although K' channels play a major role in determining resting membrane potential and repolarization of the action potential, little is known about the effects of preexisting heart disease on human atrial K' channel activity. Methods...
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Chronic heart failure is a major and increasing cause of morbidity and mortality. Although it is widely recognized that chronic heart failure affects the elderly, little attention has been given to its study specifically in this patient group. For example, patients with chronic heart failure in clinical trials frequently have an average age of around 60 years, in comparison to one of nearer 80 ...
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Although high-energy phosphate metabolism is abnormal in failing hearts [congestive heart failure (CHF)], it is unclear whether oxidative capacity is impaired. This study used the mitochondrial uncoupling agent 2,4-dinitrophenol (DNP) to determine whether reserve oxidative capacity exists during the high workload produced by catecholamine infusion in hypertrophied and failing hearts. Left ventr...
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An impairment of cardiac norepinephrine reuptake through the neuronal norepinephrine transporter promotes depletion of cardiac norepinephrine stores and local cardiac sympathetic activation in heart failure. Nerve growth factor regulates differentiation and survival of adult sympathetic cells and is decreased in failing hearts. We hypothesized that injection of nerve growth factor into stellate...
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Introduction Hyperoxia is frequently encountered in the intensive care unit (ICU) and during surgical procedures such as coronary artery bypass surgery (CABG). Higher oxygen concentrations intuitively provide a salutary oxygen reserve, but hyperoxia can induce adverse effects such as systemic vasoconstriction, reduction of cardiac output, increased microcirculatory heterogeneity and increased r...
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ژورنال
عنوان ژورنال: Nature Reviews Cardiology
سال: 2011
ISSN: 1759-5002,1759-5010
DOI: 10.1038/nrcardio.2011.99